Senescent cells undergo an irreversible and permanent arrest of cell division and are hallmarks of both the aging process and multiple chronic diseases. Senescent cells -- and more importantly the factors they secrete, known collectively as the senescence-associated secretory phenotype (SASP) -- are widely accepted as drivers of aging and multiple age-related diseases.

Taenia solium -- also called pork tapeworm -- is a parasite which causes disease around the world, particularly in very poor communities with deficient sanitation and where pigs roam free. Researchers have now analyzed the efficacy and adverse effects of three chemotherapeutics against T. solium.

Researchers are studying a valuable target in regulating the immune response in cancer and autoimmunity. VISTA is a tempering molecule that hinders T cells in the immune system from activating against self-antigens such as cancer cells. Their new publication describes how VISTA controls T-cell responses.

A biomedical research team is reporting an improvement on a microfluidic brain cancer chip. The new chip allows quick assessment of the effectiveness of cancer drugs on brain tumors.

The new study explores alpha-synuclein's basic properties, with a focus on a section of the protein known as the non-amyloidal component (NAC). The research was done on fruit fly larvae that were genetically engineered to produce both normal and mutated forms of human alpha-synuclein.

Twice as many people as previously believed are dying of sepsis worldwide, according to a new analysis. Among them are a disproportionately high number of children in poor areas.

A new study shows that cancer-causing MLL gene may also push pluripotent stem cells to make hematopoietic stem cells, a strong step in the decades-long effort to make personalizable, durable blood stem cells.

Researchers were able to track the activity of each neuron in the entire brain of zebrafish larvae and reconstruct the unfolding of neuronal events as the animals repeatedly made 'left or right' choices in a behavioral experiment. The resulting frame-by-frame view of a decision in the making was so detailed that, 10 seconds before the fish responded, the researchers could predict what their next move will be and when they would execute it.

A newly developed method can detect even low-dose human exposure to microcystins and nodularin in human urine. During harmful algal blooms (HABs), species of cyanobacteria release toxic peptides, including microcystins and nodularin into waterways, impacting wildlife and humans living in these marine environments. These findings are the first to report microcystin concentrations directly from exposed residents impacted by cyanobacteria in Florida, and is a critical step in developing and interpreting clinical diagnostic tests for HABs exposure worldwide.

Researchers have found a very high prevalence of Bartonella bacteria in tumors and tissues - but not blood samples - taken from dogs with hemangiosarcoma, a cancer of the blood vessels.

Interoception is the awareness of our physiological states. But precisely how the brain calculates and reacts to this information remains unclear. Neuroscientists now demonstrate how the insular cortex orchestrates the process. The work represents the first steps toward understanding the neural basis of interoception, which could allow researchers to address key questions in eating disorders, obesity, drug addiction, and a host of other diseases.

New research has discovered that Down's syndrome, Fragile X syndrome and Williams syndrome are all linked to sleep disruption in very young children, and that sleep plays a crucial role in the development of these children's language skills.

The International Parkinson Disease Genomics Consortium (IPDGC) has now been in existence for ten years. The consortium now reviews the progress made over the past decade in the genomics of Parkinson's disease (PD) and related disorders including Lewy body diseases, progressive supranuclear palsy, and multiple system atrophy and looks ahead at its future direction and research priorities.

Infections are a dreaded threat that can have fatal consequences after an operation, in the treatment of wounds, and during tissue engineering. Biomimetic hydrogels with 'built-in' antimicrobial properties can significantly decrease this danger. Scientists have now introduced a gel that is activated by red light to produce reactive oxygen compounds that effectively kill bacteria and fungi.