Researchers have identified a chemical compound that may be suitable as an active agent against several different unicellular parasites. Among these are the pathogens that cause malaria and toxoplasmosis. The point of attack for this promising substance is the protein tubulin: It helps cells divide and therefore is essential for the multiplication of the parasites.

A new study has uncovered neuronal circuitry in the brain of rodents that may play an important role in mediating pain-induced anhedonia -- a decrease in motivation to perform reward-driven behaviors. Researchers were able to change the activity of this circuit and restore levels of motivation in a pre-clinical model of pain tested in rodents.

Scientists have discovered a new link that could bring the scientific and medical community closer to understanding why glioblastoma, the most common malignant brain tumor, is deadlier in males than females.

The scientists' new 'binder-tag' technique allows researchers to pinpoint and track proteins that are in a desired shape or 'conformation,' and to do so in real time inside living cells. The scientists demonstrated the technique in, essentially, movies that track the active version of an important signaling protein -- a molecule, in this case, important for cell growth.

Americans may respect and admire how individual billionaires -- think Oprah Winfrey or Bill Gates -- made their billions, even as they rage against the "top 1%" as a group, new research finds.

A new study in mice has identified new treatment targets for glaucoma, including preventing a severe pediatric form of glaucoma, as well as uncovering a possible new class of therapy for the most common form of glaucoma in adults.

Despite the prevalent view that some 98% of our genome is junk DNA, new research shows that one piece of junk DNA -- the promoter of a virus-based transposon -- plays a critical role in cell proliferation and timing of embryo implantation in mice. The group found virus-based promoters linked to genes involved in development in other mammals, including humans, suggesting that transposons have been broadly repurposed for important regulatory roles.

A study suggests our brains are not optimized to calculate the shortest possible route when navigating on foot. Instead, pedestrians use vector-based navigation, choosing 'pointiest' paths that point most directly toward their destination, even if the routes are longer.

Over the last few decades, scientists have discovered that long-term calorie restriction provides a wealth of benefits in animals. Researchers have largely assumed that reduced food intake drove these benefits by reprogramming metabolism. But a new study finds that reduced calorie intake alone is not enough; fasting is essential for mice to derive full benefit.

Circadian clocks, which regulate most of the physiological processes of living beings over a rhythm of about 24 hours, are one of the most fundamental biological mechanisms. By deciphering the cell migration mechanisms underlying the immune response, scientists have shown that the activation of the immune system is modulated according to the time of day. Indeed, the migration of immune cells from the skin to the lymph nodes oscillates over a 24-hours period. Immune function is highest in the resting phase, just before activity resumes -- in the afternoon for mice, which are nocturnal animals, and early morning for humans. These results suggest that the time of day should possibly be taken into account when administering vaccines or immunotherapies against cancer, in order to increase their effectiveness.

Are animals born to seek rewards or avoid punishment? Researchers found that mice have pre-programmed neurons and circuits that process 'positive' and 'negative' stimuli. Their findings may be useful for studying neurological and psychiatric disorders in humans.

A recent study examining the therapeutic potential of photoreceptor precursors, derived from clinically compliant induced pluripotent stem cells (iPSC), has demonstrated the safety and therapeutic potential of clinically compliant iPSC-derived photoreceptor precursors as a cell replacement source for future clinical trials.

A new study examines how the extracellular matrix (ECM) -- an underlying network of molecules and proteins that provide the structure for tissue growth -- can trigger invasive cancer-related genes.

A research team led by Dr Karen Wing Yee YUEN, Associate Professor from the School of Biological Sciences at the University of Hong Kong (HKU), revealed the mechanism of artificial chromosome (AC) formation in the embryos of the model organism Caenorhabditis elegans, a 1-mm long, transparent nematode.